Neurobiology of apolipoprotein E (apoE), the mechanisms of regeneration in the brain, and the role this may play in neurodegeneration of Alzheimer's (AD).
Bruce Teter received a B.S. in marine biology and a minor in chemistry from Cal. State U., Long Beach in 1982. Dr. Teter received a Ph.D. degree in molecular biology from the University of Southern California in 1991 studying DNA structure in control of protein binding and gene expression. He then completed a postdoctoral fellowship in neurogerontology focusing on epigenetic control of gene expression changes with aging, working with Dr. Caleb Finch at the Andrus Gerontology Center in the School of Gerontology at USC. In 1996 he joined the lab of Dr. Greg Cole at UCLA and is currently Adjunct Associate Professor in the Department of Neurology, and Chief of the ApoE Research Laboratory, and Research Associate at GRECC, Veterans Administration, GLAHS.
Dr. Teter's research focuses on the neurobiology of apolipoprotein E (apoE),and how the apoE4 isotype is the major genetic risk factor for sporadic AD. Dr. Teter has published seminal works showing how apoE4 inhibits neuroplasticity. His current research examines how apoE4 increases inflammation and modulates the innate immune system, both in the brain and in peripheral blood. These phenotypes are being examined for their role in pharmacogenetic effects of apoE4 on inhibiting the efficacy of therapeutic drugs, like the omega-3 fatty acid DHA found in fish oil, and the anti-inflammatory drug curcumin, a compound in curry spice. The goal is to find ways to overcome this apoE4 inhibition of drug efficacy, possibly through the addition of exercise.