Guo, Ming, M.D., Ph.D.
  • Associate Professor of Neurology, David Geffen School of Medicine at UCLA

Guo, Ming, M.D., Ph.D.

Contact

Brain Research Institute
UCLA David Geffen School of Medicine
695 Charles Young Drive South
Los Angeles, CA 90095
Tel: (310) 206-9406
Appts: (310) 794-1195 {Neurology Clinic}
Appts: (310) 794-6039 {Memory Evaluation}
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Affiliations

Physicians

Specialty

Neurology, Neurodegenerative Disease, Alzheimer's Disease, Parkinson's Disease, Ataxia, and Neurogenetics.


Current Research

Molecular genetics of Alzheimer's disease and Parkinson's


Biography

Ming Guo, M.D., Ph.D. is an Associate Professor in Neurology, and Molecular and Medical Pharmacology at UCLA. As a Board Certified Neurologist trained at UCLA, she sees patients with neurological disorders, particularly neurodegenerative diseases and neurogenetic disorders, at the UCLA Medical Center. She draws referrals locally, as well as from out of the state and Asia. Based on her performance on the patient-based Neurology Board Certification Examination, she was selected directly by the American Board of Psychiatry and Neurology in 2003 to serve as a national Neurology Oral Board Examiner. In this capacity, she has evaluated hundreds of neurologists nationwide for their clinical competence to be Board certified. She is also an elected member of the American Neurological Association (ANA), and was awarded the ANA Derek Denny-Brown Neurological Scholar for 2009. This award is given each year to an ANA member "who has achieved a significant stature in neurological research and who promises to continue making major contributions to the field of Neurology". In addition to being a physician, Dr. Guo is also a research scientist. She received her Ph.D. from Dr. Yuh Nung Jan's laboratory at the University of California San Francisco, Howard Hughes Medical Institute (HHMI) for her work on neuronal stem cell development during asymmetric cell divisions. Following a postdoctoral training in the laboratory of Dr. Larry Zipursky at HHMI at UCLA, she became a faculty at UCLA in 2002. Currently, in addition to seeing patients, she runs a research laboratory working on molecular genetic mechanisms of neurodegenerative diseases including Parkinson's and Alzheimer's disease. Her research has been funded by several grants and awards from the National Institute of Health. In addition, she has received numerous prestigious fellowships and awards. She is an Alfred P. Sloan Foundation fellow, a McKnight Brain Disorder awardee, a Klingenstein Fellow, the 12th Robert H. Ebert Clinical Scholar of the Klingenstein Foundation, an Ellison Medical Foundation Scholar in Aging, a Larry L. Hillblom Foundation Startup Grantee.

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Education

  • M.D., Fudan University, Medical College (Formally Shanghai Medical University), China, 1989.
  • Ph.D., University of California, San Francisco (UCSF), Biomedical Sciences, 1996.
  • Postdoc., UCSF Howard Hughes Medical Institute, 1997.
  • Internship, Internal Medicine, University of California, Irvine, 1998.
  • Residency, Neurology, University of California, Los Angeles, 2001.
  • Researcher, Institute of Neurology, University of College London, Queen Square, 2000.
  • Fellowship, Neurodegenerative Disorders, UCLA Neurology, 2002.
  • Postdoc, UCLA, Howard Hughes Medical Institute, 2002.

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Honors and Awards

1989 International Fellowship, American Association of University Women (AAUW).
1989 Regents Fellowship, University of California.
1991 Nonresident Tuition Scholarship, UCSF.
1993 Nonresident Tuition Scholarship, UCSF.
2000 Annual Resident Research Award, Neurology, UCLA.
2001 Jean-Louis Riehl Award for Outstanding Research during Neurology Residency.
2001 Giannini Medical Foundation Postdoctoral Fellowship.
2001 The John Douglas French Alzheimer's Foundation Postdoctoral Fellowship.
2001 Art Linkletter Award for the Distinguished Postdoc of the Year, the John Douglas French Alzheimer's Foundation.
2002 National Institute of Health, Career Development Award for Mentored Physician Scientists (KO8).
2003-present Examiner for Neurology Oral Boards, the American Board of Psychiatry and Neurology.
2003 The Larry L. Hillblom Foundation Startup Grantee.
2003 The Ellison Medical Foundation New Scholar in Aging (2nd - 4th year support declined due to funding overlap).
2004 Alfred P. Sloan Foundation Research Fellowship in Neuroscience.
2008 Junior Faculty Preclinical Research Award, Neurology, UCLA.
2008 National Institute of Health, Career Development Award for Independent Physician Scientists (KO2).
2008 Klingenstein Foundation the 12th Robert H. Ebert Clinical Scholar (given to the most outstanding physician scientist of the year among awardees).
2008 Klingenstein Fellowship Awards in the Neuroscience.
2008 The McKnight Neuroscience Foundation Brain Disorder Award.
2009 Elected Member, American Neurological Association.
2009 Derek Denny-Brown Neurological Scholar Award, American Neurological Association (ANA) (This award is given each year to a young ANA member "who has achieved a significant stature in neurological research and who promises to continue making major contributions to the field of Neurology". The awardee presents his/her work at the annual ANA meeting.)

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Board Certifications

2003-present Board Certification in Neurology, American Board of Psychiatry and Neurology.
2003-present Examiner for Oral Board Exams, American Board of Psychiatry and Neurology (To serve as a national level Board Examiner is regarded as having a high level of professional competence).

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Publications

  • Gold MS, White DM, Ahlgren SC, Guo M, and Levine JD. Catecholamine-induced mechanical sensitization of cutaneous nociceptors in the rat. Neuroscience Letters 1994;175:166-170.
  • Guo M, Bier E, Jan LY, and Jan YN. tramtrack acts as a downstream gene of numb in specifying distinct daughters during multiple asymmetric divisions in the Drosophila PNS. Neuron 1995;14:913-925. [This paper was featured in the following review. Badenhorst, P., Harrison, S., and Travers, A. "End of the line? Tramtrack and cell fate determination in Drosophila" Genes to Cells 1996;1:707-716.]
  • Guo M, Jan LY, and Jan YN. Control of daughter cell fates during asymmetric division, interaction of Numb and Notch, Neuron 1996;17:27-41. [This paper is featured in the following review. Campos-Ortega JA. "Numb diverts Notch pathway off the tramtrack." Neuron 1996,17:1-4, and Trends in Genetics 1996; 10:399.]
  • Guo M, and Hay B. Cell proliferation and apoptosis. Current Opinion in Cell Biology 1999;11:745-752.
  • Xu P, Vernooy SY, Guo M, and Hay BA. The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Current Biology 2003;13:790-795. [This paper is featured in Cell 2003;113:673-676. The Scientist 2003;June 16. Current Biology 2003;13:R473-R475.]
  • Guo M, Hong E, Fernandes J, Zipursky SL, and Hay B. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Human Molecular Genetics 2003;12:2669-2678. (Corresponding author) [This paper is ranked "exceptional" with a ranking factor of 9.0 by Faculty of 1000 (http://www.facultyof1000.com/article/12944419).
  • Hay BA, and Guo M. Coupling cell growth, proliferation and death: Hippo weighs in. Dev. Cell 2003;5:361-363.
  • Xu P, Guo M, and Hay BA. MicroRNAs and the regulation of cell death, Trends in Genetics 2004;20:617-624.
  • Hay BA, Huh JR, and Guo M. The genetics of cell death: approaches, insights and opportunities in Drosophila, Nature Review Genetics 2004;5:911-922.
  • Huh JR, Vernooy SY, Yu H, Yan N, Shi Y, Guo M, and Hay BA. Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization. PLoS Biology 2004;1:E15 [This paper is featured in the same issue of PLOS Biology].
  • Huh JR, Guo M, and Hay BA. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Current Biology 2004;14:1262-1266.
  • Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, and Hay BA. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development 2006;133:3305-3315.
  • Huh JR, Foe I, Muro I, Chen CH, Soel JH, Yoo SJ, Guo M, Park JM, and Hay BA. The Drosophila IAP DIAP2 is dispensable for cell survival, required for the innate immune response to Gram-negative bacterial infection, and can be negatively regulated by the Reaper/Hid/Grim family of IAP-binding apoptosis inducers. J Biol Chem 2006;282:2056-2068.
  • Clark IE, Jiang C, Dodson MW, Cao J, Huh JR, Soel JH, Yoo SJ, Hay BA, and Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006;441:1162-1166. [This paper was featured/ mini-reviewed in Nature, Neuron, Cell and Lancet Neurology].
  • Chen CH, Guo M, and Hay BA. Identifying microRNA regulators of cell death in Drosophila. Methods Mol Biol 2006;342:229-240.
  • Hay BA, and Guo M. Caspase-Dependent Cell Death in Drosophila Annu. Rev. Cell. Dev Biol 2006;22:623-650.
  • Dodson MW, and Guo M. Pink1, Parkin, DJ-1 and Mitochondrial Dysfunction in Parkinson's Disease. Curr. Opin. Neurobiol 2007;17:331-337.
  • Cookson MR, Dauer W, Dawson T, Fon E, Guo M, and Shen J. The roles of kinases in familial Parkinson’s disease. J Neurosci 2007;27:11865-11868.
  • Chen C, Huang H, Ward C, Su J, Schaeffer L, Guo M, and Hay BA. A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science 2007;316:597-600. [listed #17 of "the Top 50 Research Leaders of the Year" in Scientific American (SciAm 50)in 2007].
  • Copeland JM, Bosdet I, Freeman JD, Guo M, Gorski SM, and Hay BA. Echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Dev Biol 2007;7:82.
  • Ganguly A, Feldman R, and Guo M. Ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila. Hum Mol Genet 2008;17:293-302. [Cover Story]
  • Gross GG, Feldman RM, Ganguly A, Wang J, Yu H, and Guo M. Role of X11 and ubiquilin as in vivo Regulators of Amyloid Precursor Protein in Drosophila. PLoS ONE 2008;3(6):e2495.
  • Deng H, Dodson MW, Huang H, and Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion. PNAS 2008;105:14503-14508. [This paper was selected by Thomson Reuters ScienceWatch® Essential Science IndicatorsSM as a featured New Hot Paper in the field of Neuroscience and Behavior. According to Thomson Reuters, it is one of the most-cited papers in its discipline published during the past two years.]
  • Yun J, Cao JH, Dodson MW, Kapahi P, Chowdhury RB, and Guo M. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo. J Neurosci 2008;28:14500-14510.
  • Li H, and Guo M. The protein degradation in Parkinson disease revisited: It's complex. J Clinical Invest 2009;119(3):442-445.
  • Hay BA, Chen CH, Ward CM, Huang H, Su JT, and Guo M. Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements. J Insect Physiol 2010;56:1402-1413.
  • Guo M. What have we learned from Drosophila models of Parkinson’s disease, 2010. (In press)

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