Guo, Ming, M.D., Ph.D.
  • Professor of Neurology and Pharmacology, David Geffen School of Medicine at UCLA

Guo, Ming, M.D., Ph.D.

Contact

UCLA Neurology Outpatient Clinic Westwood
300 UCLA Medical Plaza,
Suite B-200, Box 956975
Los Angeles, CA 90095-6975
Appts: (310) 794-1195
Appts: (310) 794-1195 {Neurology Clinic}
Appts: (310) 794-6039 {Memory Evaluation}
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Affiliations

Physicians

Specialty

Neurology, Neurodegenerative disease, Alzheimer's disease, Parkinson's disease, gait difficulty, and Neurogenetics.


Current Research

Genetics and therapies of Alzheimer's disease and Parkinson's disease; Aging; Neural repair.


Biography

Ming Guo, M.D., Ph.D., is Professor of Neurology and Pharmacology, and a physician scientist. Following her Neurology Residency training at UCLA, she obtained specialty fellowship training in the areas of Memory Disorder, Neurodegeneration and Neurogenetics at UCLA. As a practicing, board-certified Neurologist, she sees patients with memory disorders, neurodegenerative and neurogenetic disorders, referred from both domestic and international sources. She served as a national Neurology Oral Board Examiner for the American Board of Psychiatry and Neurology from 2003-2012. In this capacity, she has evaluated hundreds of neurologists nationwide for their clinical competence to be Board certified. She also teaches Alzheimer’s Dementia and Non-Alzheimer’s Dementia to other physicians at the UCLA Annual Neurology Review Continuing Medical Education course each year, and is a sought-after speaker at many universities and conferences domestically and internationally.

As a researcher, She received her Ph.D. from Dr. Yuh Nung Jan's laboratory at the University of California San Francisco, Howard Hughes Medical Institute (HHMI) for her work on neuronal stem cell development during asymmetric cell divisions. Following a postdoctoral training in the laboratory of Dr. Larry Zipursky at HHMI at UCLA, she became a faculty at UCLA in 2002. Her lab investigates molecular mechanisms of the two most common neurodegenerative disorders, Alzheimer's and Parkinson's disease. Mutations in PINK1 and PARKIN lead to inherited forms of Parkinson’s disease. Her lab is one of the first two labs worldwide to report the function of PINK1, and to discover that PINK1, a mitochondria-localized serine-threonine kinase, and PARKIN, an E3 ubiquitin ligase, act in a common genetic pathway to regulate mitochondrial integrity and quality control. Her work has wide-range implications for controlling processes in aging, and other aging-related diseases including other neurodegenerative disorders, heart disease and metabolic disorders.

Dr. Guo is an elected member of the American Neurological Association (ANA), the American Society of Clinical Investigation, and has received many awards. She is an Alfred P. Sloan Foundation fellow, a McKnight Neuroscience Foundation Brain Disorder Awardee, an Ellison Medical Foundation Senior Scholar in Aging, a Klingenstein-Simon’s Fellow in Neuroscience, and the Klingenstein-Simon Foundation Robert H. Ebert Clinical Scholar. Her work is also supported by the National Institute of Health (NIH) EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) award. In addition, she was selected to receive the ANA Derek Denny Brown Neurological Scholar Award that is given to one or two awardees each year, and the John Walsh Young Investigator Award, which is given to one Assistant or Associate professor every three years for their research creativity at UCLA.

Dr. Guo is actively involved in community service. She is Chair of the Board of Scientific Counselors at the National Institute of Neurological Disorders and Stroke (NIH/NINDS). Together with other 9 members with scientific expertise and leadership in the country, she participated in the first Blue Ribbon Panel to review and advise for the Intramural Research Program of the NIH/NINDS. In addition, she is on the ANA Scientific Program Advisory Committee, the Society of Neuroscience Program Committee, the Scientific Advisory Committee of the A.P. Giannini Foundation and the Scientific Selection Committee for McKnight Foundation Memory and Cognitive Disorders Award. She servces on the Editorial Board of Aging Cell (ranked 2 out of 44 journals in geriatrics and geriotology) and PLoS One. She also act at Guest Editor for PLoS Biology and Proceedings of the National Academy of Sciences (PNAS).

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Education

  • M.D., Fudan University, Medical College (Formally Shanghai Medical University), China, 1989.
  • Ph.D., University of California, San Francisco (UCSF), Biomedical Sciences, 1996.
  • Postdoc., UCSF Howard Hughes Medical Institute, 1997.
  • Internship, Internal Medicine, University of California, Irvine, 1998.
  • Residency, Neurology, University of California, Los Angeles, 2001.
  • Researcher, Institute of Neurology, University of College London, Queen Square, 2000.
  • Fellowship, Neurodegenerative Disorders, UCLA Neurology, 2002.
  • Postdoc, UCLA, Howard Hughes Medical Institute, 2002.

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Honors and Awards

1989 International Fellowship, American Association of University Women (AAUW).
1989 Regents Fellowship, University of California.
1991 Nonresident Tuition Scholarship, UCSF.
1993 Nonresident Tuition Scholarship, UCSF.
2000 Annual Resident Research Award, Neurology, UCLA.
2001 Jean-Louis Riehl Award for Outstanding Research during Neurology Residency.
2001 Giannini Medical Foundation Postdoctoral Fellowship.
2001 The John Douglas French Alzheimer's Foundation Postdoctoral Fellowship.
2001 Art Linkletter Award for the Distinguished Postdoc of the Year, the John Douglas French Alzheimer's Foundation.
2002 National Institute of Health, Career Development Award for Mentored Physician Scientists (KO8).
2003-2011 Examiner for Neurology Oral Boards, the American Board of Psychiatry and Neurology.
2003 The Larry L. Hillblom Foundation Startup Grantee.
2003 The Ellison Medical Foundation New Scholar in Aging (2nd - 4th year support declined due to funding overlap).
2004 Alfred P. Sloan Foundation Research Fellowship in Neuroscience.
2008 Junior Faculty Preclinical Research Award, Neurology, UCLA.
2008 National Institute of Health, Career Development Award for Independent Physician Scientists (KO2).
2008 Klingenstein Foundation the 12th Robert H. Ebert Clinical Scholar (given to the most outstanding physician scientist of the year among awardees).
2008 Klingenstein Fellowship Awards in the Neuroscience.
2008 The McKnight Neuroscience Foundation Brain Disorder Award.
2009 Elected Member, American Neurological Association.
2009 Derek Denny-Brown Neurological Scholar Award, American Neurological Association (ANA) (This award is given each year to a young ANA member "who has achieved a significant stature in neurological research and who promises to continue making major contributions to the field of Neurology". The awardee presents his/her work at the annual ANA meeting.)
2012 Ellison Medical Foundation In Aging Research Senior Scholar Award.
2012 The John H. Walsh Young Investigator Research Prize, given to one Assistant or Associate Professor every three years for significant contributions to basic science, translational or clinical research at UCLA School of Medicine.
2013 NIH EUREKA award (Exceptional Unconventional Research Enabling Knowledge Acceleration for Neuroscience).
2013 Association of American Medical Colleges (AAMC) Mid-Career Women Faculty Leadership Development Seminar Course.
2015 Elected Member, American Society of Clinical Investigation.

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Board Certifications

2003-present Board Certification in Neurology, American Board of Psychiatry and Neurology.
2003-present Examiner for Oral Board Exams, American Board of Psychiatry and Neurology (To serve as a national level Board Examiner is regarded as having a high level of professional competence).
2013-2023 Board 10 Year Recertification in Neurology (diplomat), American Board of Psychiatry and Neurology.

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Publications

  • Gold MS, White DM, Ahlgren SC, Guo M, and Levine JD. Catecholamine-induced mechanical sensitization of cutaneous nociceptors in the rat. Neuroscience Letters 1994;175:166-170.
  • Guo M, Bier E, Jan LY, and Jan YN. tramtrack acts as a downstream gene of numb in specifying distinct daughters during multiple asymmetric divisions in the Drosophila PNS. Neuron 1995;14:913-925. [This paper was featured in the following review. Badenhorst, P., Harrison, S., and Travers, A. "End of the line? Tramtrack and cell fate determination in Drosophila" Genes to Cells 1996;1:707-716.]
  • Guo M, Jan LY, and Jan YN. Control of daughter cell fates during asymmetric division, interaction of Numb and Notch, Neuron 1996;17:27-41. [This paper is featured in the following review. Campos-Ortega JA. "Numb diverts Notch pathway off the tramtrack." Neuron 1996,17:1-4, and Trends in Genetics 1996; 10:399.]
  • Guo M, and Hay B. Cell proliferation and apoptosis. Current Opinion in Cell Biology 1999;11:745-752.
  • Xu P, Vernooy SY, Guo M, and Hay BA. The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Current Biology 2003;13:790-795. [This paper is featured in Cell 2003;113:673-676. The Scientist 2003;June 16. Current Biology 2003;13:R473-R475.]
  • Guo M, Hong E, Fernandes J, Zipursky SL, and Hay B. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Human Molecular Genetics 2003;12:2669-2678. (Corresponding author) [This paper is ranked "exceptional" with a ranking factor of 9.0 by Faculty of 1000 (http://www.facultyof1000.com/article/12944419).
  • Hay BA, and Guo M. Coupling cell growth, proliferation and death: Hippo weighs in. Dev. Cell 2003;5:361-363.
  • Xu P, Guo M, and Hay BA. MicroRNAs and the regulation of cell death, Trends in Genetics 2004;20:617-624.
  • Hay BA, Huh JR, and Guo M. The genetics of cell death: approaches, insights and opportunities in Drosophila, Nature Review Genetics 2004;5:911-922.
  • Huh JR, Vernooy SY, Yu H, Yan N, Shi Y, Guo M, and Hay BA. Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization. PLoS Biology 2004;1:E15 [This paper is featured in the same issue of PLOS Biology].
  • Huh JR, Guo M, and Hay BA. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Current Biology 2004;14:1262-1266.
  • Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, and Hay BA. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development 2006;133:3305-3315.
  • Huh JR, Foe I, Muro I, Chen CH, Soel JH, Yoo SJ, Guo M, Park JM, and Hay BA. The Drosophila IAP DIAP2 is dispensable for cell survival, required for the innate immune response to Gram-negative bacterial infection, and can be negatively regulated by the Reaper/Hid/Grim family of IAP-binding apoptosis inducers. J Biol Chem 2006;282:2056-2068.
  • Clark IE, Jiang C, Dodson MW, Cao J, Huh JR, Soel JH, Yoo SJ, Hay BA, and Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006;441:1162-1166. [This paper was featured/ mini-reviewed in Nature, Neuron, Cell and Lancet Neurology].
  • Chen CH, Guo M, and Hay BA. Identifying microRNA regulators of cell death in Drosophila. Methods Mol Biol 2006;342:229-240.
  • Hay BA, and Guo M. Caspase-Dependent Cell Death in Drosophila Annu. Rev. Cell. Dev Biol 2006;22:623-650.
  • Dodson MW, and Guo M. Pink1, Parkin, DJ-1 and Mitochondrial Dysfunction in Parkinson's Disease. Curr. Opin. Neurobiol 2007;17:331-337.
  • Cookson MR, Dauer W, Dawson T, Fon E, Guo M, and Shen J. The roles of kinases in familial Parkinson’s disease. J Neurosci 2007;27:11865-11868.
  • Chen C, Huang H, Ward C, Su J, Schaeffer L, Guo M, and Hay BA. A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science 2007;316:597-600. [listed #17 of "the Top 50 Research Leaders of the Year" in Scientific American (SciAm 50)in 2007].
  • Copeland JM, Bosdet I, Freeman JD, Guo M, Gorski SM, and Hay BA. Echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Dev Biol 2007;7:82.
  • Ganguly A, Feldman R, and Guo M. Ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila. Hum Mol Genet 2008;17:293-302. [Cover Story]
  • Gross GG, Feldman RM, Ganguly A, Wang J, Yu H, and Guo M. Role of X11 and ubiquilin as in vivo Regulators of Amyloid Precursor Protein in Drosophila. PLoS ONE 2008;3(6):e2495.
  • Deng H, Dodson MW, Huang H, and Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion. PNAS 2008;105:14503-14508. [This paper was selected by Thomson Reuters ScienceWatch® Essential Science IndicatorsSM as a featured New Hot Paper in the field of Neuroscience and Behavior. According to Thomson Reuters, it is one of the most-cited papers in its discipline published during the past two years.]
  • Yun J, Cao JH, Dodson MW, Kapahi P, Chowdhury RB, and Guo M. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo. J Neurosci 2008;28:14500-14510.
  • Li H, and Guo M. The protein degradation in Parkinson disease revisited: It's complex. J Clinical Invest 2009;119(3):442-445.
  • Hay BA, Chen CH, Ward CM, Huang H, Su JT, and Guo M. Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements. J Insect Physiol 2010;56:1402-1413.
  • Guo M. What have we learned from Drosophila models of Parkinson’s disease. Prog Brain Res 2010;184: 3-17.
  • Rochet JC, Hay BA, Guo M. Molecular Insights into Parkinson’s Disease. Prog. Mol. Biol Transl Sci 2012;107:125-188.
  • Dodson M, Jiang C, Guo M. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum Mol Genet 2012;21:1350-1363.
  • Guo M. Drosophila as a model to study mitochondrial dysfunction in Parkinson’s Disease. Cold Spring Harb Perspct Med 2012;2(11). Pil: a009944.
  • Gross GG, Lone GM, Leung KL, HartensteinV, Guo M. X11/Mint genes control polarized localization of axonal membrane proteins in vivo. J Neurosci 2013;33:8575-8586. [The cover story and special featured].
  • Dauer WT and Guo M. Multiplying messages LRRK beneath Parkinson Disease. Cell 2014;157:291-293.
  • Dodson MW, Leung LK, Lone M, Lizzio MA, Guo M. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis Models Mech 2014;7(12):1351-1363.
  • Yun J, Puri R, Yang H, Lizzio MA, Wu CL, Sheng ZH, Guo M. MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife 2014;3:e1958. [Featured in the Editor’s Choice section of Science Signaling, newsletters from the American Parkinson Disease Association, Parkinson Disease Foundation, radios and many web-based international biomedical sites]

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