Neurology, Neurodegenerative disease, Alzheimer's disease, Parkinson's disease, gait difficulty, and Neurogenetics.
Genetics and therapies of Alzheimer's disease and Parkinson's disease; Aging; Neural repair.
Ming Guo, M.D., Ph.D., is Professor of Neurology and Pharmacology, and a physician scientist. Following her Neurology Residency training at UCLA, she obtained specialty fellowship training in the areas of Memory Disorder, Neurodegeneration and Neurogenetics at UCLA. As a practicing, board-certified Neurologist, she sees patients with memory disorders, neurodegenerative and neurogenetic disorders, referred from both domestic and international sources. She served as a national Neurology Oral Board Examiner for the American Board of Psychiatry and Neurology from 2003-2012. In this capacity, she has evaluated hundreds of neurologists nationwide for their clinical competence to be Board certified. She also teaches Alzheimer’s Dementia and Non-Alzheimer’s Dementia to other physicians at the UCLA Annual Neurology Review Continuing Medical Education course each year, and is a sought-after speaker at many universities and conferences domestically and internationally.
As a researcher, She received her Ph.D. from Dr. Yuh Nung Jan's laboratory at the University of California San Francisco, Howard Hughes Medical Institute (HHMI) for her work on neuronal stem cell development during asymmetric cell divisions. Following a postdoctoral training in the laboratory of Dr. Larry Zipursky at HHMI at UCLA, she became a faculty at UCLA in 2002. Her lab investigates molecular mechanisms of the two most common neurodegenerative disorders, Alzheimer's and Parkinson's disease. Mutations in PINK1 and PARKIN lead to inherited forms of Parkinson’s disease. Her lab is one of the first two labs worldwide to report the function of PINK1, and to discover that PINK1, a mitochondria-localized serine-threonine kinase, and PARKIN, an E3 ubiquitin ligase, act in a common genetic pathway to regulate mitochondrial integrity and quality control. Her work has wide-range implications for controlling processes in aging, and other aging-related diseases including other neurodegenerative disorders, heart disease and metabolic disorders.
Dr. Guo is an elected member of the American Neurological Association (ANA), the American Society of Clinical Investigation, and has received many awards. She is an Alfred P. Sloan Foundation fellow, a McKnight Neuroscience Foundation Brain Disorder Awardee, an Ellison Medical Foundation Senior Scholar in Aging, a Klingenstein-Simon’s Fellow in Neuroscience, and the Klingenstein-Simon Foundation Robert H. Ebert Clinical Scholar. Her work is also supported by the National Institute of Health (NIH) EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) award. In addition, she was selected to receive the ANA Derek Denny Brown Neurological Scholar Award that is given to one or two awardees each year, and the John Walsh Young Investigator Award, which is given to one Assistant or Associate professor every three years for their research creativity at UCLA.
Dr. Guo is actively involved in community service. She is Chair of the Board of Scientific Counselors at the National Institute of Neurological Disorders and Stroke (NIH/NINDS). Together with other 9 members with scientific expertise and leadership in the country, she participated in the first Blue Ribbon Panel to review and advise for the Intramural Research Program of the NIH/NINDS. In addition, she is on the ANA Scientific Program Advisory Committee, the Society of Neuroscience Program Committee, the Scientific Advisory Committee of the A.P. Giannini Foundation and the Scientific Selection Committee for McKnight Foundation Memory and Cognitive Disorders Award. She servces on the Editorial Board of Aging Cell (ranked 2 out of 44 journals in geriatrics and geriotology) and PLoS One. She also act at Guest Editor for PLoS Biology and Proceedings of the National Academy of Sciences (PNAS).