Investigators Greg Cole, Ph.D., Sally Frautschy, Ph.D., and Ed Teng, M.D., Ph.D. are studying the biology of mouse models of AD. This group has recently begun new studies of mouse models of AD that express the most well described genetic risk factor for AD; apolipoprotein E ("ApoE") gene. One of the goals of this line of research is to understand how the e4 form of ApoE contributes to AD biology and how to use this knowledge to improve AD treatments. These researchers have also done seminal work investigating the potential therapeutic effects of omega-3 fatty acid DHA found in fish oil, antioxidants (e.g. Vitamin C) and anti-inflammatory drugs, and curcumin a compound in curry spice.