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Studying the Basic Biology of Alzheimer's Disease

Purpose

The laboratories of Easton Center investigators David Teplow, Ph.D. and Gal Bitan Ph.D. focus on characterizing the subcellular interactions of the amyloid beta (Aß) protein --- considered by most to be the proximate cause of Alzheimer's disease (AD). This in vitro and in silico research examines the physical chemistry that leads to the tendency for Aß aggregate and become neurotoxic. Dr. Bitan is specifically investigating mechanisms for intervening in the aggregation process to reduce toxicity using a "tweezer" compound, which acts to interfere with a loop structure in the amyloid molecule necessary for protein aggregation and neurotoxicity.

For more information, please call the UCLA Easton Alzheimer's Disease Center at (310) 794-6039 or This email address is being protected from spambots. You need JavaScript enabled to view it. .