Bitan, Gal, Ph.D.
  • Associate Professor in Residence of Neurology, David Geffen School of Medicine at UCLA

  • Member of Brain Research Institute at UCLA

  • Member of Interdepartmental Ph.D. Program in Neuroscience at UCLA

  • Associate Member of Molecular Biology Institute at UCLA

Bitan, Gal, Ph.D.

Contact

Department of Neurology, David Geffen School of Medicine
at University of California at Los Angeles
635 Charles E. Young Drive South
Neuroscience Research Building 1, Room 451
Los Angeles, CA 90095-7334
Tel: (310) 206-2082
Fax: (310) 206-1700
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Specialty

Chemistry and Biochemistry.

Current Research

My laboratory is focused on developing novel, mechanism-based therapy for neurodegenerative diseases, including Alzheimer’s and Parkinson's diseases. We use various types of compounds and methodologies, such as peptides, peptidomimetics, and small molecules. Guiding these efforts are detailed structure–activity relationship studies, structure-based rational design, and structure-guided small scale screening efforts. To prepare and evaluate our compounds, we use techniques ranging from synthetic chemistry, through biochemical and biophysical characterization of the interaction of our compounds with their targets, toxicity assays in cell culture, and testing of lead compounds in animal models. We have identified and currently are developing several lead inhibitors of aberrant protein assembly and toxicity.

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Education

  • B.Sc. cum laude The Hebrew University of Jerusalem, Israel. Major: Chemistry and Minor: Biochemistry, 1988.
  • M.Sc. cum laude The Hebrew University of Jerusalem, Israel Organic Chemistry, 1989.
  • Ph.D. summa cum laude The Hebrew University of Jerusalem, Israel Organic Chemistry, 1996.
  • Postdoctoral fellow, Chemistry Department, Clark University, Worcester, MA. Discipline: Structural Biology, 1996-1997. (Advisor: Dale F. Mierke, Ph.D.)
  • Postdoctoral fellow, Division of Bone and Mineral Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Discipline: Peptide and protein chemistry, 1996-1999. (Advisors: Michael Rosenblatt, M.D. and Michael Chorev, Ph.D.)
  • Postdoctoral fellow, Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. Discipline: Protein folding and assembly, 1999-2003. (Advisor: David B. Teplow, Ph.D.)

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Honors and Awards

1986 Dean’s Scholarship
1987 Dean’s List
1989 Golda Meir Scholarship
2005 Turken Award for Alzheimer's Disease Research

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Publications

  • S Prabhudesai, S Sinha, A Attar, A Kotagiri, AG Fitzmaurice, R Lakshmanan, MI Ivanova, JA Loo, F-G Klärner, T Schrader, G Bitan*, and J Bronstein*. A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo. Neurotherapeutics 2012;9:464-476. *Co-corresponding authors.
  • P Novick, DHJ Lopes, K Branson, A Esteras-Chopo, IA Graef, G Bitan, and VS Pande. Design of Aβ42 aggregation inhibitors from a predicted structural motif. J. Med. Chem. 2012;55:3002–3010.
  • S Sinha, Z Du, P Maiti, F-G Klärner, T Schrader, C Wang, and G Bitan. Comparison of three amyloid assembly inhibitors – the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem. Neurosci. 2012;3:451-458.
  • S Sinha, DHJ Lopes, and G Bitan. A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity. ACS Chem. Neurosci. 2012;3:473-481
  • MM Gessel, C Wu, H Li, G Bitan, J-E Shea, and MT Bowers Aβ(39-42) Modulates Aβ Oligomerization but not Fibril Formation. Biochemistry 2012;51:108-117.
  • H Li, R Zemel, DHJ Lopes, BH Monien, and G Bitan. A two-step strategy for SAR studies of N-methylated Aβ42 C-terminal fragments as Aβ42 toxicity inhibitors. ChemMedChem 2012;7:515-522.
  • G Bitan. Can We Accelerate the Path towards Therapy for Amyloid- Related Diseases? J. Gerontol. Geriatr. Res. 2012;1:e106. doi:10.4172/jggr.1000e106.
  • JM Ringman, AT Fithian, K Gylys, JL Cummings, G Coppola, D Elashoff, D Pratico, J Moskovitz, and G Bitan. Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement. Geriatr. Cogn. Disord. 2012;33:219-225.
  • I Solomonov, E Korkotian, B Born, D Kaganovich, Y Feldman, A Bitler, AF Rahimi, H Li, G Bitan, and I Sagi. Zn2+-Aβ complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons, J. Biol. Chem. 2012;287:20555-20564.
  • C Ripoli, R Piacentini, E Riccardi, L Leone, G Bitan, and C Grassi. Synaptotoxic effects of different forms of amyloid β-protein in rodent hippocampal neurons and brain slices. Neurobiol. Aging 2012. epub ahead of print. DOI: 10.1016/j.neurobiolaging.2012.06.027.
  • A Attar, C Ripoli, E Riccardi, P Maiti, DD Li Puma, T Liu, J Hayes, MR Jones, K Lichti-Kaiser, F Yang, GD Gale, C&#$5;H Tseng, M Tan, C-W Xie, JL Straudinger, F-G Klärner, T Schrader, SA Frautschy, C Grassi, and G Bitan. Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers. Brain 2012. epub ahead of print, DOI: 10.1093/brain/aws289.
  • J Moskovitz, P Maiti, DHJ Lopes, DB Oien, A Attar, T Liu, S Mittal, J Hayes, and G Bitan. Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry 2011;50:10687–10697.
  • H Li, Z Du, DHJ Lopes, EA Fradinger, C Wang, and G Bitan. C-terminal Tetrapeptides Inhibit Aβ42-induced Neurotoxicity Primarily Through Specific Interaction at the N-terminus of Aβ42. J. Med. Chem. 2011;54:8451-8460.
  • B Urbanc, M Betnel, L Cruz, H Li, EA Fradinger, BH Monien, G Bitan. Structural basis for Aβ1-42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. J Mol Biol. 2011;410(2):316-328.
  • K Hochdörffer, J März-Berberich, L Nagel-Steger, M Epple, W Meyer-Zaika, A Horn, H Sticht, S Sinha, G Bitan, and T Schrader. Rational design of β-sheet ligands against Aβ42-induced toxicity. J. Am. Chem. Soc. 2011;133:4348-4358.
  • P Maiti, R Piacentini, C Ripoli, C Grassi, and G Bitan. Surprising assembly and toxicity behavior of amyloid β-protein oxidized to sulfone. Biochem. J. 2010;433:323-332.
  • H Li, BH Monien, A Lomakin, R Zemel, EA Fradinger, M Tan, SM Spring, B Urbanc, C-W Xie, GB Benedek, and G Bitan. Mechanistic investigation of the inhibition of Aβ42 assembly and neurotoxicity by Aβ42 C-terminal fragments. Biochemistry 2010;49:6358-6364.
  • F Rahimi and G Bitan. Selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease. J. Vis. 2010. Exp. 39, doi: 10.3791/1955.
  • P Maiti, A Lomakin, GB Benedek and G Bitan . Despite its role in assembly, methionine 35 is not necessary for amyloid β-protein toxicity. J. Neurochem. 2010;113:1252-1262.
  • B. Urbanc, M Bentel, L. Cruz, G Bitan, and DB Teplow. Elucidation of amyloid β-protein oligomerization mechanisms, J. Am. Chem. Soc. 2010;1312:4266-4280.
  • H Li, BH Monien, EA Fradinger, B Urbanc and G Bitan. Biophysical characterization of Aβ42 C-terminal fragments—inhibitors of Aβ42 neurotoxicity. Biochemistry 2010;49:1259-1267.
  • F Rahimi, K Murakami, JL Summers, C-HB Chen and G Bitan. RNA aptamers generated against oligomeric Aβ40 recognize common amyloid aptatopes with high sensitivity, PLoS ONE, 4, e7694. 2009. doi:10.1371/journal.pone.0007694.
  • SK Maji, RR Ogorzalek Loo, M Inayatullah, SM Spring, SS Vollers, MM Condron, G Bitan, JA Loo, and DB Teplow. Amino acid position-specific contributions to amyloid β-protein oligomerization. J. Biol. Chem. 2009;284:23580-23591.
  • SL Bernstein, NF Dupuis, ND Lazo, T Wyttenbach, MM Condron, G Bitan, DB Teplow, J-E Shea, BT. Ruotolo, CV. Robinson, and MT Bowers. Why Aβ42 is the neurotoxic agent in Alzheimer's disease, not Aβ40: early oligomer studies. Nat. Chem. 2009;1:326-331.
  • C Wu, SL Bernstein, M Murray, MM Condron, G Bitan, MT Bowers, and J-E Shea. Structural characterization of amyloid β-protein C-terminal fragments. J. Mol. Biol. 2009;387:492-501.
  • F Rahimi, P Maiti, and G Bitan. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. J. Vis. Exp., 2009. doi: 10.3791/1071.
  • EA Fradinger, BH Monien, B Urbanc, A Lomakin, M Tan, H Li, SM Spring, MM Condron, L Cruz, C-W Xie, GB Benedek, and G Bitan. C-terminal peptides co-assemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity. Proc. Natl. Acad. Sci. USA 2008;105:14175–14180.
  • MM Condron, BH Monien, and G Bitan. Synthesis and purification of highly hydrophobic peptides derived from the C-terminus of amyloid β-protein. Open Biotechnol, J. 2008;2:87-93.

Chapters

  • F Rahimi and G Bitan. The structure and function of fibrillar and oligomeric assemblies of amyloidogenic proteins. In: Pre-fibrillar amyloidogenic protein assemblies-common cytotoxins underlying degenerative diseases. F Rahimi and G Bitan, Eds. Springer Science+Media B.V., Dordrecht. 2012;1-36.
  • C Rosensweig, K Ono, K Murakami, D Lowenstein, G Bitan, and DB Teplow. Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods Mol. Biol. 2012;489:23-31.
  • DHJ Lopes, S Sinha, C Rosensweig, and G Bitan. Application of Photochemical Cross-linking to the Study of Oligomerization of Amyloidogenic Proteins. Methods Mol. Biol. 2012;489:11-22.
  • H Li, F Rahimi, K Murakami, P Maiti, S Sinha, and G Bitan. "Amyloids and protein aggregation–analytical methods" In: Encyclopedia of Analytical Chemistry, Ed. R. A. Meyers, John Wiley: Chichester. 2009. DOI: 10.1002/9780470027318.a9038.
  • H Li and G Bitan. SAR and Mechanistic Studies of Tetrapeptide Inhibitors of Aβ42-Induced Neurotoxicity. In: M. Lebl, Ed. Breaking Away: Proceedings of the 21st American Peptide Symposium. 2009;189-190.

  • H Li, BH Monien, A Lomakin, EA Fradinger, SM Spring, B Urbanc, GB Benedek, and G Bitan. Investigation of Aβ42 C-Terminal Fragments as Inhibitors of Aβ42 Assembly and Neurotoxicity. In: M. Lebl, Ed. Breaking Away: Proceedings of the 21st American Peptide Symposium. 2009;187-188.
  • A Shanmugam, BH Monien, and G Bitan. Development in Diagnostic and Therapeutic Strategies for Alzheimer’s Disease. In: Sun M-K, Ed. Research Progress in Alzheimer’s Disease and Dementia. Vol. 3. Nova Science Publisher, Inc. 2008;193-250.
  • G Bitan. Structural study of metastable amyloidogenic protein oligomers by Photo-Induced Cross-linking of Unmodified Proteins (PICUP). Methods Enzymol. 2006;413:217-236.
  • SM Spring, SL Bernstein, ND Lazo, B Urbanc, HE Stanley, MT Bowers, DB Teplow, and G Bitan. Towards Inhibition of Amyloid β-protein Oligomerization. In: Blondelle SE ed. Understanding Biology Using Peptides, American Peptide Society. 2006;515-516.

Research Abstracts

2012

  • Alzheimer's Association International Conference, Vancouver, BC, Canada 2012. A Attar, C Ripoli, E Riccardi, T Liu, MR Jones, F Yang, C-H Tseng, F-G Klärner, T Schrader, SA Frautschy C Grassi, and G Bitan. Lysine-specific molecular tweezers as an Aβ-targeting therapy for Alzheimer's disease protect neurons against Aβ-induced synaptotoxicity and lower Aβ and p-tau load in a mouse model of Alzheimer's disease.
  • Alzheimer's Association International Conference, Vancouver, BC, Canada 2012. S Sinha, DHJ Lopes, Z Du, P Maiti, F-G Klärner, T Schrader, C Wang, and G Bitan. Structural insight into the mechanism of Aβ toxicity and its inhibition by small molecules.
  • The 60th ASMS Conference on Mass Spectrometry and Allied Topics Vancouver, BC, Canada 2012. P Wongkongkathep, J Zhang, G Bitan, F-G Klärner, T Schrader, and JA Loo. Native Protein Surface Mapping using Lysine-specific Compounds and Top-Down Mass Spectrometry.
  • The 9th World Brain Mapping Conference, Toronto, ON, Canada 2012. G Bitan. Aberrant protein self-assembly as a general target for Alzheimer's disease therapy.
  • The 42nd Annual Meeting of the Society for Neuroscience, New Orleans, LA 2012. A Attar and G Bitan. Brain penetration of amyloid assembly and toxicity inhibitor, CLR01, in 12-month- and 24-month-old wild-type and transgenic mice.
  • The 42nd Annual Meeting of the Society for Neuroscience, New Orleans, LA 2012. G Bitan, A Attar, S Sinha, DHJ Lopes, P Maiti, MR Jones, F Yang, SA Frautschy, S Prabhudesai, JM Bronstein, F Richter, M-F Chesselet, Z Du, C Wang, C Ripoli, E Riccardi, C Grassi, F-G Klärner, T Schrader. Molecular tweezers inhibit protein aggregation and toxicity in vitro and in vivo.

2011

  • The 8th International Brain Research Organization (IBRO) World Congress of Neuroscience, Florence, Italy 2011. C Ripoli, E Riccardi1, R Piacentini1, L Leone, G Bitan, and C Grassi. Effects of different forms of amyloid β-peptide on synaptic function.
  • The 8th International Brain Research Organization (IBRO) World Congress of Neuroscience, Florence, Italy 2011. DHJ Lopes, S Sinha, and G Bitan. A key role for lysine residues in amyloid β-protein folding, assembly and toxicity.
  • The 41st Annual Meeting of the Society for Neuroscience, Washington, DC 2011. DHJ Lopes, P Maiti, J Moskovitz, and G Bitan. Induction of methionine-sulfoxide reductase protects neurons from amyloid β-protein insults in vitro and in vivo.
  • The 41st Annual Meeting of the Society for Neuroscience, Washington, DC 2011. G Bitan, S Sinha, and DHJ Lopes. Lysine residues are key mediators of amyloid β-protein folding, assembly, and toxicity.
  • The 41st Annual Meeting of the Society for Neuroscience, Washington, DC 2011. A Attar, T Liu, K Lei, M Nejad, J Hayes, and G Bitan. Assessment of spatial memory in 4- and 15-month old 3×Tg Alzheimer's mice by Barnes maze using short versus long training.
  • The 55th Annual Meeting of the Biophysical Society, Baltimore, MD 2011. B Urbanc, B Barz, M Betnel, L Cruz, G Bitan, and DB. Teplow. Structural basis for amyloid β-protein toxicity inhibition: a multiscale computational study.
  • The 42nd Annual Meeting of the American Society for Neurochemistry, St. Louis, MO 2011. G Bitan, A Attar, JM Bronstein, M-F Chesselet, Z Du, M Ehrmann, SA Frautschy, MR Jones, F-G Klärner, T Liu, JA Loo, DHJ Lopes, P Maiti, ES Pang, S Prabhudesai, F Richter, T Schrader, S Sinha, P Talbiersky, M Tan, A Tennstädt, C Wang, C-W Xie, and F Yang. Molecular Tweezers - potential therapeutics for amyloid-related diseases.
  • The 59th ASMS Conference on Mass Spectrometry, Denver, CO 2011. MT Bowers, M Gessel, C Wu, J-E Shea, X Zheng, H Li, and G Bitan. Interaction of ligands with Alzheimer's and type 2 diabetes amyloid forming monomers using IMS-MS: Screening potential drug candidates.

2010

  • Conference on Ion Chemistry and Mass Spectrometry, Lake Arrowhead, CA 2010. M Murray, H Lee, S Sinha, G Bitan, and MT Bowers. Inhibition of Amyloid-β Aggregation.
  • Conference on Ion Chemistry and Mass Spectrometry, Lake Arrowhead, CA 2010. ES Pang, S Yin, G Bitan, DB Teplow, and JA Loo. Using Top-Down ECD to Identify the Sites of Molecular Tweezer Noncovalent Binding to Amyloid β-Protein.
  • The 54th Annual Meeting of the Biophysical Society, San Francisco, CA 2010. D Lopes, K McDaniel, and G Bitan. Novel Inhibitors of IAPP assembly and cytotoxicity.
  • International Conference on Alzheimer’s Disease, Honolulu, HI 2010. A Attar, S Sinha, P Maiti, F Yang, D Gant, M Jones, P Talbiersky, T Schrader, F-G Klärner, SA Frautschy, and G Bitan. Small molecule inhibitor of amyloid β-protein oligomerization reduces brain Aβ load in an Alzheimer’s disease mouse model.
  • International Conference on Alzheimer’s Disease, Honolulu, HI 2010. G Bitan, S Sinha, A Attar, P Maiti, M Tan, S Prabhudesai, P Talbiersky, R Bakshi, P-Y Kuo, F Yang, D Gant, MR Jones, C-W Xie, JM Bronstein, SA. Frautschy, F-G Klärner, and T Schrader. Novel, small molecule inhibitors of protein aggregation for treatment of amyloid-related diseases.
  • International Conference on Alzheimer’s Disease, Honolulu, HI 2010. P Maiti, A Lomakin, GB Benedek, and G Bitan. Is methionine 35 really necessary for amyloid β-protein toxicity?

  • International Conference on Alzheimer’s Disease, Honolulu, HI 2010. P Maiti, J Moskovitz, R Piacentini, C Ripoli, A Lomakin, C Grassi, GB Benedek, and G Bitan. Aβ-sulfoxide but not Aβ-sulfone reduces neurotoxicity through the methionine sulfoxide reductase system.
  • International Conference on Alzheimer’s Disease, Honolulu, HI 2010. JM Ringman, AT Fithian, K Gylys, JL Cummings, G Coppola, D Pratico, J Moskovitz, and G Bitan. Methionine sulfoxide, an index of oxidative stress, measured in plasma of persons with familial Alzheimer's disease mutations.
  • The 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT 2010. E Pang, S Yin, G Bitan, T Schrader, JA Loo, and DB Teplow. Probing the Sites of Molecular Tweezer Noncovalent Binding to Amyloid β-Protein using Top-Down ECD-FT-ICR MS.
  • The 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT 2010. MM. Murray, H Li, G Bitan, and MT Bowers. Mass Spectrometry-Ion Mobility Spectrometry to Investigate the Interaction of Alzheimer’s Amyloid β-Protein and Aggregation Inhibitors.
  • The 24th Symposium of the Protein Society, San Diego, CA 2010. H Li, EA Fradinger, and G Bitan. Mechanistic Investigation of Tetrapeptide Inhibitors of Aβ42-Induced Neurotoxicity.
  • The 24th Symposium of the Protein Society, San Diego, CA 2010. D Lopes, K McDaniel, T Schrader, F-G Klärner, and G Bitan. Novel inhibitors of IAPP assembly and neurotoxicity.
  • The 24th Symposium of the Protein Society, San Diego, CA 2010. D Lopes, S Sinha, A Tennstädt, M Ehrmann, F-G Klärner, T Schrader, and G Bitan. Molecular Tweezers as broad-spectrum inhibitos of amyloid protein aggregation and toxicity.
  • The 40th Annual Meeting of the Society for Neuroscience, San Diego, CA 2010. H Li, EA Fradinger, R Zemel, and G Bitan, Rational design peptide-based inhibitors for Aβ42-induced neurotoxicity.
  • The 40th Annual Meeting of the Society for Neuroscience, San Diego, CA 2010. B Urbanc, B Barz, M Betnel, M Cruz, G Bitan, and DB Teplow. Elucidation of amyloid β­protein oligomerization pathways in the absence and presence of toxicity inhibitors: A multiscale computational study.
  • The 40th Annual Meeting of the Society for Neuroscience, San Diego, CA 2010. C. Ripoli, E Riccardi, R Piacentini, P Maiti, G Bitan, and C Grassi. Role of the redox state of methionine 35 in the synaptotoxicity of amyloid-β peptide.

  • The 40th Annual Meeting of the Society for Neuroscience, San Diego, CA 2010. A Attar, S Sinha, P Maiti, M Tan, R Bakshi, F Yang, MR Jones, C-W Xie, F-G Klärner, T Schrader, SA Frautschy, and G Bitan, Molecular tweezers reduce amyloid β-protein burden in transgenic mice by inhibiting Aβ assembly.
  • The 40th Annual Meeting of the Society for Neuroscience, San Diego, CA 2010. G Bitan, S Sinha, DH Lopes, A Attar, K McDaniel, R Bakshi, S Prabhudesai, J Bronstein, F Richter, C Zhu, M-F Chesselet, T Schrader, and F-G Klärner, Molecular tweezers are broad-spectrum protein aggregation showing promise for Parkinson’s disease therapy.
  • The 62nd Annual Meeting of the American Neurological Association, San Francisco, CA 2010. S. Prabhudesai, S. Sinha, G. Bitan, and JM Bronstein. A Small-molecule Inhibitor of α-Synuclein Neurotoxicity.

2009

  • The 53rd Annual Meeting of the Biophysical Society, Boston, MA 2009. B Urbanc, G Bitan, L Cruz, A Lam, and DB Teplow. Computational study of assembly and toxicity inhibition of amyloid β-protein and its arctic mutant.
  • 9th International Conference on AD/PD, Prague, Czech Republic 2009. G Bitan, H Li, S Sinha, A Attar, P-Y Kuo, R Bakshi, T Schrader, P Talbiersky, J Polkowska, T Gersthagen, G Benedek, A Lomakin, C-W Xie, M Tan, B Urbanc, L Cruz, S Frautschy, F Yang, S Hu, D Gant, M Bowers, M Murray, J-E Shea, and C Wu. Rationally designed inhibitors of amyloid β-protein assembly and toxicity.
  • 9th International Conference on AD/PD, Prague, Czech Republic 2009. A Attar, S Sinha, P-Y Kuo, R Bakshi, T Schrader, P Talbiersky, J Polkowska, T Gersthagen, G Benedek, A Lomakin, C-W Xie, M Tan, S Frautschy, F Yang, S Hu, D Gant, and G Bitan. Rationally designed small molecule inhibitor of amyloid β-protein assembly rescues spatial working memory deficits in a mouse model of Alzheimer’s disease.
  • 21st Ameican Peptide Symposium, Bloomington, IN 2009. H Li, BH Monien, A Lomakin, EA Fradinger, SM Spring, B Urbanc, GB Benedek, and G Bitan. Investigation of Aβ42 C-Terminal Fragments as Inhibitors of Aβ42 Assembly and Neurotoxicity.
  • 21st Ameican Peptide Symposium, Bloomington, IN 2009. H Li and G Bitan. SAR and Mechanistic Studies of Tetrapeptide Inhibitors of Aβ42-Induced Neurotoxicity.
  • Cell Death and Differentiation Conference on Neurodegeneration, Rome, Italy 2009. C Ripoli, R Piacentini, G Leoni, P Maiti, GB Azzena, G Bitan, and C Grassi. Amyloid-β peptide (Aβ)-induced dysregulation of intracellular Ca2+ signaling in rat neocortical neurons depends upon the chemical state of methionine 35.
  • The 23rd Symposium of the Protein Society, Boston, MA 2009. S Sinha, A Attar, P-Y Kuo, R Bakshi, P Maiti, P Talbiersky, A Lomakin, M Tan, E Pang, Z Du, F Yang, S Hu, D Gant, M Jones, C Wang, J Loo5, S Frautschy, C-W Xie, G Benedek, T Schrader, and G Bitan. Rationally identified small molecules inhibit amyloid β-protein assembly and toxicity by a novel mechanism.
  • The 39th Annual Meeting of the Society for Neuroscience, Chicago, IL 2009. F Rahimi, K Murakami, JL Summers, C-H B Chen, and G Bitan. Aptamers generated against oligomeric Aβ40 recognize common amyloid aptatopes with high sensitivity.
  • The 39th Annual Meeting of the Society for Neuroscience, Chicago, IL 2009. H Li, D Lopes, and G Bitan. Tetrapeptides Protect Neurons Against Aβ42-Induced Neurotoxicity.
  • The 39th Annual Meeting of the Society for Neuroscience, Chicago, IL 2009. H Li, BH Monien, A Lomakin, EA Fradinger, SM Spring, B Urbanc, GB Benedek, and G Bitan. Mechanistic Investigation of Aβ42 C-terminal Fragments as Aβ42 Assembly and Neurotoxicity Inhibitors.
  • The 39th Annual Meeting of the Society for Neuroscience, Chicago, IL 2009. G Bitan, S Sinha, A Attar, P-Y Kuo, R Bakshi, T Schrader, F-G Klärner, P Talbiersky, J Polkowska, S Frautschy, F Yang, S Hu, D Gant, J Bronstein, S Prabhudesai, C-W Xie, M Tan, GB Benedek, and A Lomakin. Rational, structure-based small molecule inhibitors of protein assembly show promise for Alzheimer’s and Parkinson’s diseases.
  • The 39th Annual Meeting of the Society for Neuroscience, Chicago, IL 2009. P Maiti, R Piacentini, C Ripoli, C Grassi, J Moskovitz, and G Bitan. Is methionine sulfoxide reductase the reason for the lower toxicity of oxidized versus reduced Aβ?
  • The 39th Annual Meeting of the Society for Neuroscience, Chicago, IL 2009. A Attar, S Sinha, P-Y Kuo, R Bakshi, F Yang, S Hu, D Gant, P Talbierksy, F-G Klärner, T Schrader, S Frautschy, and G Bitan. Small molecule inhibitors of amyloid β-protein oligomerization reverse deficits in spatial working memory in an Alzheimer's disease mouse model.
  • The 57th ASMS Conference on Mass Spectrometry, Philadelphia, PA 2009. E Pang, S Yin, G Bitan, DB Teplow, and JA Loo. Identifying the Sites of Small Molecules and Amyloid β-Protein Noncovalent Interactions Using Top-Down Mass Spectrometry.

2008

  • The 22nd Symposium of the Protein Society, San Diego, CA 2008. J Summers, F. Rahimi, K Murakami, and G Bitan. Aptamers selected against monomeric Aβ40 recognize other amyloid proteins.
  • The 56th ASMS Conference on Mass Spectrometry, Denver, CO 2008. M Murray, C Wu, S Bernstein, MM Condron, G Bitan, J-E Shea, and M Bowers. The Aβ Alzheimer's Peptide: Experiment and Theory on C-terminal Fragments.

Reviews

  • T Liu and G Bitan. Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms. ChemMedChem. 2012;7:359-374.
  • F Rahimi, A Shuanmugam, and G Bitan. Structure–Function Relationships of Pre-Fibrillar Protein Assemblies in Alzheimer's Disease and Related Disorders. Curr. Alz. Res. 2008;5:319-341.
  • BH Monien, LG Apostolova, and G Bitan. Early diagnostics and therapeutics for Alzheimer’s disease - how early can we get there? Expert Rev. Neurotherapeutics 2006;6:1293-1306.
  • DB Teplow, ND Lazo, G Bitan, SL Bernstein, T Wyttenbach, MT Bowers, A Baumketner, J-E Shea, B Urbanc, L Cruz, J Borreguero, and HE Stanley. Elucidating Amyloid β-protein Folding and Assembly: A Multidisciplinary Approach. Acc. Chem. Res. 2006;39:635-645.
  • G Bitan. Molecular Neurobiology of Alzheimer Disease and Related disorders [Book Review]. Amyloid: J Protein Folding Disord. 2005;12:65-66.
  • G Bitan and DB Teplow. Rapid photochemical cross-linking – a new tool for studies of metastable, amyloidogenic protein assemblies. Acc. Chem. Res. 2004;37:357-364.
  • MD Kirkitadze, G Bitan, and DB Teplow. Paradigm shifts in Alzheimer's and other neurodegenerative diseases: The emerging role of oligomeric assemblies. J. Neurosci. Res. 2002;69:567-577.

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