Dr. Frautschy focus in her graduate & initial post-graduate work was to understand the adverse effects of chronic stress on physiology, intrigued by the work of Hans Selye who in 1956 coined a word "stress" from physics to use to describe the physiological/chemical response to an emotional reaction. She worked under experts in the field of 'stress', completing her MS under the late Gary Moberg at UC Davis in 1980 and PhD in 1986 under Professor Robert Liptrap, DVM, PhD at Univ. of Guelph, Ontario Canada (also a photographer.) After completing her PhD, she trained with Dipak Sarkar (UCSD, now at Rutgers), another neuroendocrinogist. During her 2nd post doc with Dr. Andrew Baird & directorship of Roger Guillemin (a nobel laureate who did his post doc under Hans Selye), Sally worked on brain injury induction of neurotrophic factors where she bega her collaboration with Dr. Cole. Many neurotrophic factors become elevated in the Alzheimer brain as a 'response' to injury. In 1988, Dr. Frautschy, in collaboration with Dr. Cole, decided to evaluate the brain's response to human amyloid, and was the first to describe the inflammatory response. Since then, her priority has been to develop practical and effective approaches, particularly nutritional, for stopping this tragic disease, which in part, evolves from a personal experience with head injury.