Ringman, John M., M.D., M.S.
  • Clinical Professor of Neurology, David Geffen School of Medicine at UCLA

  • Associate Clinical Director, Mary S. Easton Center for Alzheimer's Disease Research at UCLA

Ringman, John M., M.D., M.S.

Contact

Mary S. Easton Center for Alzheimer's Disease Research at UCLA
10911 Weyburn Avenue, Suite 200
Los Angeles, CA 90095-7226
Tel: (310) 794-3665
Fax: (310) 794-3148
Appointments: (310) 794-6039 {Memory Evaluation}
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Specialty

Neurology, Alzheimer's Disease, Dementia, and Memory Disorders.

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Education

  • B.A., Highest honors, Neurobiology and Psychology, University of California, Berkeley, CA, 1988.
  • M.D., Medical School, McGill Faculty of Medicine, Montreal, Quebec, Canada, 1993.
  • Internship, Internal Medicine, Baylor Department of Medicine, Houston, TX, 1994.
  • Residency, Neurology, Baylor Department of Neurology, Houston, TX, 1997.
  • Fellowship, Neurobehavioral and Dementia, UCLA Department of Neurology, Los Angeles, CA, 1999.
  • Masters of Science, Clinical Research, UCLA Department of Biomathematics, Los Angeles, CA, 2008.

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Honors and Awards

1986 Phi Beta Kappa
1990 Francis McNaughton Book Prize for performance in the McGill Medical School course on central nervous system anatomy
1998 First Prize, Gustaf Retzius Neuroanatomy Competition
2003-2005 Shirley and Jack Goldberg Neuroscience Scholar
2004 Turken Research Award for work in Alzheimer’s Disease

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Board Certifications

2007-2017 Board Certification in Behavioral Neurology and Neuropsychiatry, United Council for Neurologic Subspecialties
2000-2010 Board Certification in Neurology, American Board of Neurology and Psychiatry
1997-Present Medical Board of California
1998-2000 Medical Board of Alaska
1997-2006 Drug Enforcement Agency
1994 Diplomate, National Board of Medical Examiners

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Publications (selected peer-reviewed publications)

  • Ringman JM, Rodriguez Y, Diaz-Olavarrieta C, Chavez M, Thompson M, Fairbanks L, Paz F, Varpetian A, Chaparro H, Macias-Islas MA, Murrell J, Ghetti B, Kawas C. Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementia. Int Psychogeriatr. 2007 Apr;19(2):323-332. PMID: 16805926
  • Nelson LD, Scheibel KE, Ringman JM, Sayre JW. An experimental approach to detecting dementia in Down syndrome: A paradigm for Alzheimer's disease. Brain Cogn. 2007 Jun;64(1)92-103. PMID: 17383786
  • Ringman JM, O'Neill J, Geschwind D, Medina L, Apostolova LG, Rodriguez Y, Schaffer B, Varpetian A, Tseng B, Ortiz F, Fitten J, Cummings JL, Bartzokis G. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain. 2007 Jul;130 (Pt 7):1767-1776. PMID: 17522104
  • Fiala M, Liu PT, Espinoza-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci USA. 2007 Jul 31;104(31):12849-12854. PMID: 17652175; PMCID: PMC1937555
  • Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S., Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer's disease. Neurology. 2008 Jul 8:71(2):85-92. PMID: 18509095
  • Ringman JM, Rao PN, Lu PH, Cederbaum S. Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review. Arch Neurol. 2008 Mar;65(3):412-415. PMID: 18332257
  • Teng E, Ringman JM, Ross LK, Mulnard RA, Dick MB, Bartzokis G, Davies HD, Galasko D, Hewett L, Mungas D, Reed BR, Schneider LS, Segal-Gidan F, Yaffe K, Cummings JL; Alzheimer's Disease Research Centers of California-Depression in Alzheimer's Disease Investigators. Diagnosing depression in Alzheimer's disease with the National Institute of Mental Health provisional criteria. Am J Geriatr Psychiatry. 2008 Jun;16(6):469-477. PMID: 18515691; PMCID: PMC2989660
  • Ringman JM, Romano JD, Medina LD, Rodriguez-Agudelo Y, Schaffer B, Varpetian A, Ortiz F, Fitten J, Cummings JL, Baloh RW. Increased prevalence of significant recurrent headaches in preclinical familial Alzheimer's disease mutation carriers. Dement Geriatr Cogn Disord. 2008 ;25(4):380-384. PMID: 18376127
  • Ringman JM, Mozaffar T. Myopathy associated with chronic orlistat consumption: a case report. Neuromuscul Disord. 2008 May 18(5):410-412. PMID: 18430571
  • Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland SD, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr;66(4):448-457. PMID: 19364929; PMCID: PMC2742778
  • Golob EJ, Ringman JM, Irimajiri R, Bright S, Schaffer B, Medina LD, Starr A. Cortical event-related potentials in preclinical familial Alzheimer's disease. Neurology. 2009 Nov 17;73(20):1649-1655. PMID: 19917987; PMCID: PMC2788802
  • Portelius E, Andreasson U, Ringman JM, Buerger K, Daborg J, Buchave P, Hansson O, Harmsen A, Gustavsson MK, Hanse E, Galasko D, Hampel H, Blennow K, Zetterberg H. Distinct cerebrospinal fluid amyloid peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease. Mol Neurodegener. 2010 Jan 14;5:2. PMID: 20145736; PMCID: PMC2818651
  • Ringman JM, Pope W, Salamon N. Insensitivity of visual assessment of hippocampal atrophy in familial Alzheimer's disease. J Neurol. 2010 May;257(5):839-842. PMID: 20047059; PMCID: PMC2864895
  • Ringman JM, Kwon E, Rotko C, Mendez MF, Lu P. The use of profanity during letter fluency tasks in frontotemporal dementia and Alzheimer's disease. Cogn Behav Neurol. 2010 Sep;23(3):159-164. PMID 20829665
  • Braskie MN, Medina LD, Rodriquez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer SY, Ringman JM. Increased fMRI signal with age in familial Alzheimer’s disease mutation carriers. Neurobiol Aging. 2010 Dec 1. PMID: 21129823
  • Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, Goate AM, Bird TD, Leverenz JB. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer’s disease due to a novel PSEN1 mutation. Neurosci Lett. 2011 Jan 10;487(3):287-292. PMID: 21094210; PMCID: PMC3034479
  • Ringman JM, Medina LD, Braskie M, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA. Cummings JL, Bookheimer S. Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer’s disease mutations during a novelty encoding task. Cereb Cortex. 2011 Apr;21(4):877-883.PMID: 20729396; PMCID: PMC3059887
  • Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin GN, Wright JM, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4;31(18):6764-6770. PMID: 21543606
  • Ringman JM, Taylor K, Teng E, Coppola G, Gylys K. Longitudinal change in CSF biomarkers in a presymptomatic carrier of an app mutation. Neurology. 2011 May 11. [Epub ahead of print] PMID: 21562250

Chapters

  • Ringman JM, Cummings JL. Pharmacological Interventions for Cognition in Dementia. In: Cognitive Rehabilitation. Stuss DT, Winocur G, Robertson IH, eds. Cambridge University Press; 2008:334-347.
  • Ringman JM, Cummings JL. The Genetic Basis for the Cognitive Deterioration of Alzheimer's Disease. In: The Genetics of Cognitive Neuroscience. Goldberg TE, Weinberger DR, eds. MIT press; 2009:221-244.
  • Ringman JM, Varpetian A. Other Dementias. In: International Neurology. Lisak RP, Truong DD, Carroll WM, Bhidayasiri R, eds. Wiley-Blackwell; 2009:137-143.
  • Ringman JM, Vinters HV. Alzheimer's Disease and the Frontotemporal Dementia Syndromes. In: Textbook of Geriatric Neuropsychiatry, 3rd edition. Coffey EC, Cummings JL, eds. American Psychiatric Press; 2011:407-425.

Reviews

  • Jarvik L, LaRue A, Blacker D, Gatz M, Kawas C, McArdle JJ, Morris JC, Mortimer JA, Ringman JM, Ercoli L, Freimer N, Gokhman I, Manly JJ, Plassman BL, Rasgon N, Roberts JS, Sunderland T, Swan GE, Wolf P, Zonderman AB. Children of Persons with Alzheimer's Disease: What Does the Future Hold? Alzheimer Dis Assoc Disorder. 2008 January-March;22(1):6-20. PMID: 18317242
  • Ringman JM, Medina LD, Rodriguez-Agudelo Y, Lu P, Cummings JL. Current Concepts of Mild Cognitive Impairment and their Applicability to Persons At-Risk for Familial Alzheimer's Disease. Curr Alzheimer Res. 2009 Aug;6(4):341-346. PMID: 19689233; PMCID: PMC2887763
  • Ringman JM, Grill J, Rodriguez-Agudelo Y, Chavez M, Xiong C. Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Prevention trials in persons at risk for dominantly inherited Alzheimer's disease: opportunities and challenges. Alzheimers Dement. 2009 Mar;5(2):166-171. PMID: 19328453; PMCID: PMC2746429
  • Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther. 2011 Jan 6;3(1):1. PMID: 21211070
  • Braskie MN, Ringman JM, Thompson PM. Neuroimaging measures as endophenotypes in Alzheimer's disease. Int J Alzheimers Dis. 2011 Mar 31;2011:490140. PMID: 21547229; PMCID: PMC3087508

Letters, Editorials, and Historical Essays

  • Ringman JM. Serendipitous Improvement in the Yips Associated with Memantine Use. Mov Disord. 2007 Mar 15;22(4):598-599. PMID: 17266082
  • Ringman JM. The Huntington Disease of Woody Guthrie: Another Man Done Gone. Cogn Behav Neurol. 2007 Dec;20(4):238-243. PMID: 18091075
  • Cummings JL, Ringman J, Metz K. Mary S. Easton Center of Alzheimer's Disease Research at UCLA: Advancing the Therapeutic Imperative. J Alzheimers Dis. 2010;19(2):375-388. PMID: 20110588; PMCID: PMC2855886
  • Ringman JM. Setting the stage for prevention of familial Alzheimer's disease. Lancet Neurology. 2011 Mar;10(3):200-201. PMID: 21296021

Multicenter Publications in which Dr. Ringman was a Contributor

  • Kurlan R, Cummings J, Raman R, Thal L; Alzheimer's Disease Cooperative Study Group. Quetiapine for agitation or psychosis in patients with dementia and parkinsonism. Neurology. 2007 Apr 24;68(17):1356-1363. PMID: 17452579
  • Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S. Stokes KT, Thomas RG, Thal LJ; Alzheimer’s Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA. 2008 Oct 15;300(15):1774-1783. PMID: 18854539; PMCID: PMC2684821
  • Jun G,...Ringman JM...et al. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010 Dec;67(12):1473-1484. PMID: 20697030; PMCID: PMC3048805
  • Naj AC,...Ringman JM...et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May;43(5):436-441. PMID: 21460841; PMCID: PMC3090745

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