Grill, Joshua, Ph.D.
  • Assistant Adjunct Professor, Department of Neurology

  • P. Gene and Elaine Smith Term Chair in Alzheimer's Disease Research

  • Director, Katherine and Benjamin Kagan Alzheimer's Disease Treatment Development Program

  • Director, Recruitment and Education Core

Grill, Joshua, Ph.D.

Contact

Mary S. Easton Center for Alzheimer's Disease Research at UCLA
10911 Weyburn Avenue, Suite 200
Los Angeles, CA 90095-7226
Tel: (310) 794-2511
Fax: (310) 794-3148
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Specialty

Neuroscience, Alzheimer's Disease, and Clinical Trials.

Current Research

Clinical trials of new medications for Alzheimer's disease.

Education

  • B.A., Major in Psychology and Zoology, Minor in Neuroscience, Miami University, Oxford, OH, 1999.
  • Ph.D., Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, 2004.

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Publications

  • Grill JD, Raman R, Ernstrom K, Aisen P, Karlawish J. Study partner impact on Alzheimer's disease clinical trials (accepted, Neurology).
  • Grill JD, Karlawish J, Elashoff D, Vickrey BG. Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment. Alzheimer's & Dementia: Journal of the Alzheimer's Association. 2012, Nov [Epub ahead of print]. PMID: 23141383
  • Grill JD, Monsell S, Karlawish J. Are patients whose study partners are spouses more likely to be eligible for Alzheimer's disease clinical trials? Dementia & Geriatric Cognitive Disorders. 2012;33(5):334-340. PMID: 22759982; PMCID: PMC3477789 [Available on 2013/7/2]
  • Grill JD, Di L, Lu P, Lee C, Ringman J, Apostolova L, Chow N, Kohannim O, Cummings JL, Thompson P, Elashoff D, for the Alzheimer's Disease Neuroimaging Initiative. Estimating sample sizes for pre-dementia Alzheimer’s trials based on the Alzheimer’s Disease Neuroimaging Initiative. Neurobiol Aging. 2012, April 12 [Epub ahead of print]. PMID: 22503160; PMCID: PMC3412892 [Available on 2014/1/1]
  • Grill JD, Ringman JM. Should persons with autosomal dominant AD be included in clinical trials? Alzheimer's Research and Therapy. 2011;3(3):18. PMID: 21609419; PMCID: PMC3226307
  • Grill JD, Karlawish J. Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials. Invited review, Alzheimer's Research and Therapy. 2010;2:34. PMID: 21172069; PMCID: PMC3031880
  • Grill JD, Cummings JL. Current therapeutic targets for Alzheimer's disease. Expert Reviews in Neurotherapeutics. 2010;10(5):711-728. PMID: 20420492
  • Ringman JM, Grill J, Rodriguez-Agudelo Y, Chavez M, Xiong C. Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008." Prevention trials in persons at risk for dominantly inherited Alzheimer's disease: opportunities and challenges. Alzheimer's and Dementia: Journal of the Alzheimer's Association. 2009;5:166-171. PMID: 19328453; PMCID: PMC2746429
  • Grill JD, Cummings JL. "My patient can't stop laughing": Involuntary Emotional Expression Disorder. Current Psychiatry. 2008;7:101-111.
  • Robinson-Smith GR, Grill JD. Recognizing involuntary emotional expression disorder. Journal of Neuroscience Nursing. 2007;39:202-207. PMID: 17847666
  • Grill JD, Sonntag WE, Riddle DR. Dendritic regulation in a model of adult-onset IGF-1 deficiency. Growth Hormone and IGF-1 Research. 2005;15(5):337-348. PMID: 16143551
  • Grill JD, Riddle DR. Age-related and laminar-specific dendritic changes in the medial frontal cortex of the rat, Brain Research. 2002;937(1-2):8-21. PMID: 12020857
  • Grill JD, Coghill RC. Transient analgesia evoked by noxious stimulus offset, Journal of Neurophysiology. 2002;87:2205-2208. PMID: 11929939

Chapters

  • Grill JD, Cummings JL. Disease Modifying Therapies in development for Alzheimer's disease. In: Neurobiology of Mental Illness (Fourth Edition). Charney D, Buxbau J, Sklar P, Nestler E, and Holtzman D, Eds. (in press)
  • Grill JD, Cummings JL. Clinical Trials in Alzheimer's disease. In: Clinical Trials: From Ideas to Implementation. Cummings JL, Poole T, and Ravina B, Eds. (in press)

Abstracts

  • Walter S, Shaffer-Bacareza E, Chavez R, Woods K, Matthews G, Aisen P, Grill J. Examining start up for a multi-center clinical trial of neurosurgical administration of Nerve Growth Factor gene transfer. Clinical Trials in Alzheimer's Disease, Meeting Abstracts, 2012.
  • Grill JD, Raman R, Ernstrom K, Aisen P, Karlawish J. Alzheimer's disease clinical trial participants with adult child study partners are underrepresented and may experience slower cognitive decline. Alzheimer's Association International Conference, Meeting Abstracts, 2012.
  • Dilley M, Mason K, Silverman DH, Quach J, Beigi M, Ringman JM, Cummings JL, Grill JD. Medium-term ketogenic medical food consumption in Alzheimer's disease enhances the acute cerebral blood flow response in specific frontocortical and basal ganglia regions. Alzheimer's Association International Conference, Meeting Abstracts, 2012.
  • Dosanjh K, Di LJ, Kotlerman J, Elashoff D, Ringman JM, Grill JD. A pilot survey to explore attitudes and opinions regarding primary prevention, secondary prevention, and Alzheimer's disease treatment clinical trials. Alzheimer's Association International Conference, Meeting Abstracts, 2012.
  • Grill JD, Di L, Elashoff D, Lu PH, Kohannim O, Apostolova LG, Ringman JM, Cummings JL, Thompson PM, the Alzheimer's Disease Neuroimaging Initiative. Estimating sample sizes for predementia Alzheimer's disease clinical trials based on the Alzheimer's Disease Neuroimaging Initiative. Clinical Trials in Alzheimer's Disease, Meeting Abstracts, 2011.
  • Grill JD, Elashoff D, Hazel J, Berman R, Coric V. Examining recruitment in a Phase II multisite industry-sponsored interventional trial in mild-to-moderate Alzheimer's disease. Clinical Trials in Alzheimer's Disease, Meeting Abstracts, 2011.
  • Dilley M, Silverman DH, Cummings JL, Grill JD. A 45 day regimen of caprylidene (Axona®) increases regional cerebral blood flow responses in the forebrain of subjects with mild-to-moderate Alzheimer's disease. World Molecular Imaging Conference, Meeting Congress, 2011.
  • Coric V, Seibyl J, Minton M, Ross J, Brody M, Curtis C, Richter R, Hayes W, Yoo B, Grill JD, Feldman H, Berman RM. Correlation between baseline measures of amyloid-positron emission tomography (PET) imaging, cerebral spinal fluid (CSF) biomarkers, and clinical scales in Predementia Alzheimer's Disease (AD). Abstract was presented at the Alzheimer's Association International Conference 2011 (AAIC 2011), Paris, France, July July 16th-21st, 2011.
  • Joshua Grill, Ph.D.1, Megan Hooper, M.S.2, Yaneth Rodriguez-Agudelo, Ph.D.3, Luis D. Medina, B.A.4, John M. Ringman, M.D., M.S.1. 1Mary S. Easton Center for Alzheimer's Disease Research at UCLA, 2Genetic Counseling Program, Cal State University Northridge, CA, 3National Institute of Neurology and Neurosurgery, Mexico City, 4SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA. The influence of the availability of prevention trials on genetic testing decisions in persons at-risk for familial Alzheimer's disease. Poster was presented at the 63rd American Academy of Neurology (AAN) Meeting, Honolulu, Hawaii, April 9th-16th, 2011.
  • Joshua Grill, Ph.D.1,2, Jason Karlawish, M.D.5, David Elashoff, Ph.D.1,3, Lijie Di, M.S.1,3, Barbara Vickrey, M.D., M.P.H.2,4. 1Mary Easton Center for Alzheimer's Disease Research, 2Department of Neurology, 3Department of Medicine, UCLA David Geffen School of Medicine, 4VA Greater Los Angeles Healthcare System, and 5Penn Memory Center, Penn Center for Bioethics, Departments of Medicine and Medical Ethics. Factors Important to Cognitively Normal Adults in Decisions about Alzheimer's Disease Secondary Prevention Trial Participation. Poster was presented at the 63rd American Academy of Neurology (AAN) Meeting, Honolulu, Hawaii, April 9th-16th, 2011.
  • Grill JD, Forbes ME, Riddle DR. Activation of the type-1 IGF receptor does not elicit dendritic growth of cortical neurons. Society for Neuroscience Abstracts, 2004.
  • Grill JD, Riddle DR. Dendritic regulation in a model of adult-onset IGF-1 deficiency. Society for Neuroscience Abstracts, 2003.
  • Grill JD, Karlawish J, Vickrey B. Factors important to Cognitively Normal Adults in Decisions about Alzheimer's Disease Secondary Prevention Trial Recruitment. American Academy of Neurology, Meeting Abstracts, 2001.
  • Grill JD, Riddle DR. Age-related and laminar-specific dendritic changes in medial frontal cortex. Society for Neuroscience Abstracts, 2001.
  • Grill JD, Coghill RC. Offset Analgesia: Pain Suppression Induced by Dynamic Alterations of Noxious Stimulus Intensity. Society for Neuroscience Abstracts, 2000.
  • Corcoran K, Berno S, Grill J. Effects of Alcohol on Hippocampal Place Cell Activity; Dose-Dependant and Time Dependent Effects. Miami University Undergraduate Poster Session, 1999.
  • Berno S, Grill J, Corcoran K. Effects of Alcohol on Hippocampal Place Cell Activity; Dose-Dependent and Time Dependent Effects. Miami University Psychology Department Undergraduate Poster Session, 1999.

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