Jagodzinska, Barbara, Ph.D.
  • Senior Medicinal Chemist, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA

Jagodzinska, Barbara, Ph.D.

Contact

Drug Discovery Laboratory
UCLA Department of Neurology
3242 Reed, 710 Westwood Plaza,
Los Angeles, CA 90095-1769
Tel: (310) 206-4478
Fax: (310) 825-6956
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Lab website: https://drugdiscovery.neurology.ucla.edu

 

Specialty

Medicinal Chemistry, Drug Discovery, Therapeutic candidates for Alzheimer’s disease (AD) and CNS disorders. Analoging by searching and pharmacophore building based on SAR and computational modeling.

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Biography

Dr. Jagodzinska is a medicinal chemist, member of a Drug Discovery & Translational Laboratory at the Department of Neurology at UCLA with many years of drug discovery experience in the pharmaceutical industry (Elan Pharmaceuticals, Novartis and Kelsius Inc.). She is a member of the Alzheimer’s Disease Program in the Mary S. Easton Center for Alzheimer's Disease. Previously Dr. Jagodzinska was with Athena Neurosciences and Elan Pharmaceuticals for ~20 years where she was part of project teams developing drug candidates for CNS disorders. Next, for the several years Dr. Jagodzinska consulted the Alzheimer's Drug Development Network (ADDN), a network that was originally co-founded by Drs. John and Bredesen at the Buck Institute for Research on Aging in Novato. At ADDN she focused on drug discovery with novel targets in neurodegenerative diseases and AD through analoging and small molecule optimization for potency and bioavailability. In collaboration with the Dominican University of California she established a Medicinal Chemistry Laboratory for preparation and characterization of analogs.

During her tenure at Elan Pharmaceuticals, Dr. Jagodzinska was part of the γ-secretase and BACE inhibitor program teams. Systematically designed and synthesized a family of inhibitors and identified a target specific nanomolar lead candidates as effective inhibitors of APP processing. She acted as a liaison between Chemistry and Pharmacology during optimization phase of the AD project during collaboration between Elan and Pharmacia, later Pfizer.

Dr. Jagodzinska is an author of over 40 publications and pending patents on compounds and analogs for CNS related targets.

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Education

  • Ph.D. Natural Product Chemistry, University of Warsaw, Poland.
  • Fellow, Dr. Carl Djerassi Laboratory, Stanford University.

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Publications (Selected)

  • Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the treatment of Alzheimer's disease. ACS Chem Biol. 2020,15(6):1671-1684.
  • Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, Cole G, LaDu MJ, Jung ME, Bredesen DE, John V. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model. Sci Rep. 2018;8:17574. PMCID: PMC6279743
  • Campagna J, Vadivel K, Jagodzinska B, Bilousova T, Spilman P, John V. Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol Biol. 2018;430(11):1566-1576. PMID: 29649434
  • Bilousova T, Elias C, Miyoshi E, Alam MP, Zhu C, Campagna J, Vadivel K, Jagodzinska B, Gylys KH, John V. Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochemical and Biophysical Research Communications 2018;499(4):751-757. PMCID: PMC5956110
  • Poksay K, Sheffler D, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. Screening for small molecule inhibitors of statin-induced APP C-terminal toxic fragment production. Frontiers in Experimental Pharmacology and Drug Discovery 2017;8:46. PMCID: PMC5309220
  • Alam MP, Jagodzinska B, Campagna J, Spilman P, John V. C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides. Tetrahedron Letters 2016;57(19):2059-2062. PMCID: PMC4852388
  • Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. A?PP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer's Disease. J Alzheimer’s Disease 2013 ;37(2):343-355. PMCID: PMC3971881
  • Probst GD, Bowers S, Sealy JM, Stupi B, Dressen D, Jagodzinska BM, Aquino J, Gailunas A, Truong AP, Tso L, Xu YZ, Hom RK, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Sham HL, Jagodzinski J, Toth G, Brecht E, Yao N, Pan H, Lin M, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Gauby S, Zmolek W, Quinn KP, Sauer JM. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure-activity relationship of the aryl region. Bioorg Med Chem Lett. 2010; 20(20):6034-6039. PMID: 20822903
  • Sealy JM, Truong AP, Tso L, Probst GD, Aquino J, Hom RK, Jagodzinska BM, Dressen D, Wone DW, Brogley L, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Dappen MS, Toth G, Pan H, Ruslim L, Miller J, Bova MP, Sinha S, Quinn KP, Sauer JM. Design and Synthesis of cell-potent BACE-1 inhibitors: structure-activity relationship of P1’ substituents. Bioorg. Med. Chem. Lett. 2009;19(22):6386-6391. PMID: 19811916
  • Jagodzinska BM, Sealy JM, Wone D, Garofalo AW, Thorsett ED, Wu J, Dovey HF, Bales C, Latimer LH. New functional gamma-secretase inhibitor succinic-diamides for the treatment of Alzheimer's disease. ACS Nat Mtg, San Diego, CA, 2001;1-5.
  • Jagodzinska BM, Trimmer JS, Fenical W, Djerassi C. Sterols in marine invertebrates. 49. Isolation and structure elucidation of eight new polyhydroxylated sterols from the soft coral Sinularia dissecta. Journal of Organic Chemistry 1985, 50(9), 1435-9
  • Jagodzinska BM, Trimmer JS, Fenical W, Djerassi C. Sterols in marine invertebrates. 51. Isolation and structure elucidation of C-18 functionalized sterols from the soft coral Sinularia dissecta. Journal of Organic Chemistry (1985), 50(16), 2988-92

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