Drug Discovery and Translational Laboratory

The laboratory is focused on discovery and development of drug candidates for neurodegenerative diseases primarily for Alzheimer’s disease. The laboratory is setup to be multifunctional and equipped for chemistry and biology. Activities include most aspects of preclinical drug discovery, from development of phenotypic screens and target validation, to medicinal chemistry for hit-to-lead optimization, in vitro ADMET studies for lead advancement, in vivo pharmacokinetic (PK) / pharmacodynamic (PD) testing for target engagement, and lead confirmation. The laboratory is part of the UCLA Alzheimer's Drug Development Network (ADDN), a multi-site network leveraging key UCLA capabilities and outside resources to develop novel therapeutics for AD, at the Mary S. Easton Center for Alzheimer's disease Research at UCLA. For more information, please visit the Drug Discovery Laboratory website.

Latest publicatons:

  • Alam, M.P., Bilousova, T., Spilman, P., Vadivel, K., Bai, D., Elias, C.J., Evseenko, D., John, V. (2018). A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. ACS Chem. Neurosci. 9 (3), 462-8.
  • Bilousova, T., Elias, C., Miyoshi, E., Alam, M.P., Zhu, C., Campagna, J., Vadivel, K. Jagodzinska, B., Gylys, K., John, V. (2018). Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. BBRC (Just accepted)
  • Campagna, J.; Vadivel, K.; Jagodznska, B.; Jun, M.; Bilousova, T.; Spilman, P.; John, V. (2018). Evaluation of an Allosteric Inhibitor Peptide to identify mimetics that can interact with the Loop F region of BACE and prevent APP cleavage. JMB-D-17-00802R2 (Just accepted)

Zhu, Chunni, Ph.D.
Drug Discovery Lab, Easton Center Alzheimer's Disease Research Center at UCLA, Los Angeles, California Associate Project Scientist, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

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